Coagulation- platelets and clotting factors are responsible for initiating coagulation. When an injury occurs platelets ( thrombocytes) immediately migrate to the damaged area. Because platelets stick to each other (aggregation) and to the vessel walls (adhesion), they form a plug around the injured tissue. Plasma clotting factors reach the platelet plug and interact with each other to form a stable blood clot. Hemostasis is the balance between clot formation and clot breakdown that occurs throughout the day.
Anticoagulants commonly known as blood thinners. Drugs used to decrease the clot formation in blood vessels. These drugs are used as preventive measures to protect the patient from conditions like stroke, heart attack, myocardial infarction.
The mechanism of anticoagulation determines the onset and duration of drug action.Heparin has a quick onset and duration of action because the anticoagulant effect occurs as soon as the thromboplastin drug complex is formed.
Warfarin has a longest onset and duration of action because it takes days to clear the normal clotting factors before an effect can be observed.
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